Microgest 100mg Capsule 10pcs

✔️ Uses of Microgest 100mg Capsule

• Hormone Replacement Therapy
• Female infertility
• Endometrial hyperplasia
• Secondary Amenorrhoea

✔️ How does Microgest 100mg Capsule work?

Microgest 100mg Capsule contains progesterone, which is a hormone found in females. It acts on the uterine lining to promote and sustain pregnancy in women who have difficulty conceiving. Additionally, it provides protection to the uterus from the harmful effects of estrogen when used to treat symptoms of menopause.

✔️ Side Effects of Microgest 100mg Capsule

• Headache
• Mood swings
• Vaginal discharge
• Breast pain and tenderness
• Muscle or joint pain
• Constipation
• Fatigue
• Joint pain
• Cough
• Abnormal menstrual bleeding
• Musculoskeletal (bone, muscle, or joint) pain
• Slurred speech
• Pain behind eyes
• Depression
• Breast lumps
• Loss of vision or blurred vision
• Unexpected vaginal bleeding
• Swelling of face, lips, eyelids, tongue, hands and feet
• Nausea or Vomiting

✔️ Quick Suggestions:

• Microgest 100mg Capsule is a natural progesterone available as a micronized formulation which helps in better absorption of this medicine.
• It is used as a part of hormone replacement therapy generally in combination with estrogen.
• It may also be used in the treatment of problems related to menstrual periods such as amenorrhea (absence of periods).
• It also helps in the maintenance of pregnancy in women who are at higher risk of miscarriage.
• It should be taken with food.
• Reduce carbohydrate intake and eat more antioxidant-rich foods.
• Avoid consumption of alcohol. & Quit smoking.
• Caffeine and caffeinated drinks should be avoided for improved fertility.
• Prior to taking this medicine, your physician will perform a cervical screening and conduct a physical examination of your pelvic region and breasts.
• Your physician will also monitor for any uterine abnormalities that may occur during treatment, such as an increased thickness of the endometrial lining (endometrial hyperplasia), and will examine your blood vessels for any indications of blood clots.

✔️ Indication

• Progesterone is used to treat disorders that result from a deficiency of progesterone, such as premenopause, menopause (in combination with estrogen), menstrual irregularities, premenstrual syndrome, benign mastopathies, and secondary amenorrhea.
• In addition, it can also prevent the thickening of the endometrial lining of the uterus in non-hysterectomized postmenopausal women who are taking conjugated estrogens.

✔️ Pharmacology

Micronized progesterone is a form of progesterone that is identical to the progesterone naturally produced by the body. It is available in soft gel capsules, and its bioavailability is increased due to the micronization process. When taken after meals, the serum progesterone levels in the body reach their highest point. Progesterone has a high affinity for binding to blood proteins, with about 96-99% of it binding to these proteins, primarily serum albumin. In the liver, progesterone is converted to pregnanediol and pregnanolones. These metabolites are eliminated from the body in the form of glucuronide and sulfate conjugates through the bile and urine.

✔️ Dosage & Administration of

• The recommended dose of progesterone is typically 100mg to 200mg per day, taken orally or vaginally in divided doses. However, the dosage may vary based on the condition being treated and the individual needs of the patient.
• Progesterone can be used to maintain pregnancy in cases of threatened or recurrent abortion, with a recommended dosage of 200mg to 400mg per day in divided doses.
• For in-vitro fertilization and embryo transfer, the recommended dosage is 200mg taken three times a day starting on the day of embryo transfer until pregnancy is confirmed. If pregnant, the dosage can be continued until the 12th week of pregnancy.
• For hormone replacement therapy, the recommended dosage varies based on the regimen being used. In a sequential regimen, 200mg of progesterone is taken daily for the last two weeks of each therapeutic cycle. In a continuous regimen, 100mg of progesterone is taken daily throughout the month in conjunction with estrogen.
• Progesterone can also be used in the oocyte donation program, with a recommended dosage of 100mg taken twice a day from the day of transfer until pregnancy is confirmed. The dosage may be increased to a maximum of 600mg per day and continued until the 12th week of pregnancy.
• For luteal support, progesterone is taken at a dosage of 100mg three times a day starting on the 17th day of the cycle for 10 days in an induced cycle. If pregnant, the dosage is continued until the 12th week of pregnancy.
• In cases of luteal phase insufficiency, the dosage of progesterone is gradually increased up to a maximum of 600mg per day in divided doses if required. For secondary amenorrhea, a dosage of 300mg of progesterone taken for 10 days can result in withdrawal bleeding in 80% of cases.
• For premenstrual syndrome, the recommended dosage is 100-200mg of progesterone taken daily for 10 days from the 17th to the 26th day of each menstrual cycle. For benign mastopathy, a dosage of 200-300mg of progesterone is typically taken for 10 days per month, usually from the 17th to the 26th day of the monthly cycle.

Administration:

• Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Microgest 100 is to be taken with food. Check the label for directions before using the tablet. Insert the tablet into the vagina using the applicator. the doctor will decide the correct dose and duration of therapy for you based on your age, body weight, and disease condition.

✔️ Interaction

Microgest 100mg Capsule may interact with various medicines and should not be taken with certain medications. Inform your doctor if you are taking any of the following medicines before taking Microgest 100mg Capsule:

• Medicines used to treat epilepsy such as carbamazepine, phenytoin, phenobarbital
• Medicines used to treat bacterial infections such as rifampicin, rifabutin, ampicillin, and tetracyclines like doxycycline and minocycline
• Medicines used to treat HIV infection such as nelfinavir, nevirapine, efavirenz, ritonavir
• St. John's wort (used to treat depression)
• Bromocriptine (used to stop breast milk production, treat infertility, or parkinsonism)
• Cyclosporine (used to prevent graft rejection)
• Medicines used to treat fungal infections such as griseofulvin, ketoconazole, terbinafine
• Spironolactone (used to treat fluid retention)
• Other progesterone medicines used to treat hormonal problems such as medroxyprogesterone acetate and megestrol
• Medicines used to prevent or treat blood clots such as warfarin and phenindione
• Medicines used to treat diabetes such as glimepiride and metformin
• Ulipristal (used to prevent pregnancy in emergencies)
• Tizanidine (used to treat multiple sclerosis)

Microgest 100mg Capsule should not be taken with food as it may increase the bioavailability of this medicine.

✔️ Contraindications

Progesterone should not be used in individuals who have a history of hypersensitivity to the drug, hepatic dysfunction, undiagnosed vaginal bleeding, porphyria, uterine and genital organ malignancies, breast cancers, and a history of stroke or blood clot. Additionally, it should not be used in cases where there is tissue remaining in the uterus after a miscarriage.

✔️ Pregnancy & Lactation

• Microgest 100mg Capsule is not recommended for use in pregnant women or those who might become pregnant. It is for use in postmenopausal women only.
• Microgest 100mg Capsule is not recommended for use in breastfeeding women.

✔️ Precautions & Warnings

• It is important to discuss your medical history and any potential risk factors with your healthcare provider before starting Microgest 100mg Capsule. Women with a family history of breast cancer, DVT/PE, current or history of depression, endometriosis, DM, HTN, bone metabolic disease, renal or hepatic impairment, or conditions exacerbated by fluid retention (such as migraine, asthma, epilepsy) should use caution when taking this medication.
• It is important to monitor for signs of side effects such as jaundice, visual problems, VTE, severe depression, increased blood pressure, and migraine with unusual severity. If any of these develop, the medication should be discontinued immediately.
• Patients who are on warfarin, or oral anticoagulants, or have an increased risk of thromboembolic complications after surgery should also use caution and may require an increase in anticoagulant dose.
• Women who use oral contraceptives may have an increased risk of breast and cervical cancer, as well as liver cancer. The risk of these cancers may increase with long-term use of oral contraceptives.
• Microgest 100mg Capsules may cause dizziness, so it is important to use caution when driving or operating machinery. It should also be used with caution in patients with a history of depression or diseases that could become exacerbated by fluid retention including epilepsy, migraine, renal dysfunction, diabetes, or asthma.

✔️ Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.